Complementary DNA sequence of human amyloidogenic immunoglobulin light-chain precursors
نویسندگان
چکیده
منابع مشابه
Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain.
Light-chain amyloidosis (AL) is a degenerative disease characterized by the extracellular aggregation of a destabilized amyloidogenic Ig light chain (LC) secreted from a clonally expanded plasma cell. Current treatments for AL revolve around ablating the cancer plasma cell population using chemotherapy regimens. Unfortunately, this approach is limited to the ∼ 70% of patients who do not exhibit...
متن کاملAn Immunoglobulin Light Chain
Identification of the immunogens responsible for the production of pathogenic autoantibodies is a major problem in the field of autoimmunity. In the principal diseases that are thought to involve autoimmunization, rheumatoid arthritis, type I diabetes, and multiple sclerosis are examples, the instigating stimulus is unknown. Another example of the gap in our knowledge of disease-causing immunog...
متن کاملHuman immunoglobulin D: genomic sequence of the delta heavy chain.
The DNA coding for the human immunoglobulin D(IgD) heavy chain (delta, delta) has been sequenced including the membrane and secreted termini. Human delta, like that of the mouse, has a separate exon for the carboxyl terminus of the secreted form. This feature of human and mouse IgD distinguishes it from all other immunoglobulins regardless of species or class. The human gene is different from t...
متن کاملAtypical immunoglobulin light chain amyloidosis
BACKGROUND Primary immunoglobulin light chain amyloidosis (AL amyloidosis) is a plasma cell disorder which mainly affects heart, kidneys, liver, and peripheral nervous system. Cases of atypical AL amyloidosis presented as spontaneous vertebral compression fractures have been rarely reported, and data about the management and clinical outcomes of the patients are scarce. METHODS Herein, we pre...
متن کاملFunctional Immunoglobulin Light Chain Genes
Rearrangement of Ig genes proceeds during B cell differentiation in an orderly fashion. First the heavy (H) chain gene is rearranged in pre-B cells . These cells can express cytoplasmic A chain but no light (L) chain (1). The K light chain genes rear range next and if they fail to produce a functional gene on either chromosome the X light chain genes are rearranged (2) . It is generally believe...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1992
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2850149